| Fecha | Local | Visitante | Resultado |
|---|---|---|---|
| 11/12/25 18:45 | AC Fiorentina | Dinamo de Kiev | 2:1 |
| 11/12/25 18:45 | Jagiellonia Bialystok | Rayo Vallecano de Madrid | 1:2 |
| 11/12/25 18:45 | KF Drita Gjilan | AZ Alkmaar | 0:3 |
| 11/12/25 18:45 | Breidablik Kopavogur | Shamrock Rovers | 3:1 |
| 11/12/25 18:45 | Samsunspor | AEK Athenas | 1:2 |
| 11/12/25 18:45 | KF Shkendija | SK Slovan Bratislava | 2:0 |
| 11/12/25 18:45 | BK Häcken | AEK Larnaka | 1:1 |
| 11/12/25 18:45 | Universitatea Craiova | Sparta Praga | 1:2 |
| 11/12/25 18:45 | FC Noah | Legia Varsovia | 2:1 |
| 11/12/25 21:00 | SK Rapid Viena | Omonia Nicosia | 0:1 |
| 11/12/25 21:00 | Lech Poznan | FSV Mainz 05 | 1:1 |
| 11/12/25 21:00 | HNK Rijeka | NK Celje | 3:0 |
| 11/12/25 21:00 | Lincoln Red Imps FC | Sigma Olomouc | 2:1 |
| 11/12/25 21:00 | Kuopion PS | FC Lausanne-Sport | 0:0 |
| 11/12/25 21:00 | FC Aberdeen | Racing Club Strasbourg | 0:1 |
| 11/12/25 21:00 | KS Rakow Czestochowa | HŠK Zrinjski Mostar | 1:0 |
| 11/12/25 21:00 | Hamrun Spartans | Shaktar Donetsk | 0:2 |
| 11/12/25 21:00 | FC Shelbourne | Crystal Palace | 0:3 |