| Fecha | Local | Visitante | Resultado |
|---|---|---|---|
| 2/10/25 18:45 | Rayo Vallecano de Madrid | KF Shkendija | -:- |
| 2/10/25 18:45 | Jagiellonia Bialystok | Hamrun Spartans | -:- |
| 2/10/25 18:45 | Lech Poznan | SK Rapid Viena | -:- |
| 2/10/25 18:45 | Omonia Nicosia | FSV Mainz 05 | -:- |
| 2/10/25 18:45 | FC Noah | HNK Rijeka | -:- |
| 2/10/25 18:45 | FC Lausanne-Sport | Breidablik Kopavogur | -:- |
| 2/10/25 18:45 | HŠK Zrinjski Mostar | Lincoln Red Imps FC | -:- |
| 2/10/25 18:45 | Kuopion PS | KF Drita Gjilan | -:- |
| 2/10/25 18:45 | Dinamo de Kiev | Crystal Palace | -:- |
| 2/10/25 21:00 | NK Celje | AEK Athenas | -:- |
| 2/10/25 21:00 | FC Shelbourne | BK Häcken | -:- |
| 2/10/25 21:00 | AEK Larnaka | AZ Alkmaar | -:- |
| 2/10/25 21:00 | FC Aberdeen | Shaktar Donetsk | -:- |
| 2/10/25 21:00 | KS Rakow Czestochowa | Universitatea Craiova | -:- |
| 2/10/25 21:00 | Sparta Praga | Shamrock Rovers | -:- |
| 2/10/25 21:00 | SK Slovan Bratislava | Racing Club Strasbourg | -:- |
| 2/10/25 21:00 | Legia Varsovia | Samsunspor | -:- |
| 2/10/25 21:00 | AC Fiorentina | Sigma Olomouc | -:- |